Εight Rwandan children leave their families behind to embark on a life-or-death journey seeking high-risk heart surgery in Sudan. Their hearts ravaged by a treatable disease from childhood strep throat, they have only months left to live. Open Heart reveals the intertwined endeavors of Dr. Emmanuel, Rwanda's lone government cardiologist fighting to save the lives of his young patients, and Dr. Gino, the Salam Center's head surgeon, who is fighting to save his hospital, Africa's only link to life-saving free cardiac surgery for the millions who need it.